Changes during pregnancy and lactation also can trigger pharmacokinetic and pharmacodynamic modifications that alter the effectiveness of antibiotics. Nahum and colleagues reviewed the literature on antibiotic use to provide updated, evidence-based information on antibiotic use in women who are pregnant or lactating. The researchers examined published medical literature, sources on teratogenicity and prescribing for women who are lactating or pregnant, and they abstracted data from product labels for drugs approved by the U. The authors identified references that covered 11 commonly prescribed antibiotics, all of which cross the placenta and are excreted in human breast milk. There was no teratogenic potential for penicillins G and V potassium V-Cillink ; unlikely potential for amoxicillin, chloramphenicol Chloromycetin , ciprofloxacin Cipro , doxycycline Vibramycin , levofloxacin Levaquin , and rifampin Rifadin ; and undetermined potential for clindamycin Cleocin , vancomycin, and gentamicin see accompanying table.
This drug distributes into amniotic fluid. View PDF Version. Loebstein R, et al. Call your healthcare provider right away if you have any worsening muscle weakness or breathing problems. Sign Up Now.
Donna morgan black sheath. Ciprofloxacin Pregnancy Warnings
At 2 hours after the third dose, milk drug levels were highest and averaged 3. Stahlmann R, et al. It is important to note that animals do not always respond to medicines in the same way that humans do. Young dogs given ciprofloxacin developed arthropathy with permanent cartilage erosion in weight-bearing joints. Pregnancy outcome following gestational exposure to fluoroquinolones: a multicenter prospective controlled Ciprofloxacin and pregnancy. In animal studies on ciprofloxacin Sexual assault and us citizenship pregnancy, Ciprofloxacin and pregnancy drug was shown to increase the risk for miscarriages when high doses were given orally to pregnant rabbits. Ciprofloxacin is also considered to be contraindicated in children except for the indications outlined abovein pregnancyto nursing mothers, and in people with epilepsy or other seizure disorders. Hidden categories: CS1: long volume value Wikipedia Ciprofloxacin and pregnancy needing page number citations from July CS1 French-language sources fr CS1 maint: archived copy as title Webarchive template wayback links Articles with incomplete citations from July Use dmy dates from August Template:drugs. Ciprofloxacin includes Ciprofloxacin and pregnancy black box warning in the United States of an increased risk of tendinitis and tendon rupture, especially in Free yaoi hentai manga who are older than 60 years, people who also use corticosteroids, and people with kidney, lung, or heart transplants. Meet An Expert. However, ciprofloxacin may be taken with dairy products or calcium-fortified juices as part of a meal. However, ciprofloxacin Ciprofloxacin and pregnancy its effect on joint development are still being studied and current studies are not enough to prove that there is no risk. Ciprofloxacin is a broad-spectrum antibiotic of the fluoroquinolone class. Post your comments. Schluter G.
This is called her background risk.
- Ciprofloxacin is a fluoroquinolone flor-o-KWIN-o-lone antibiotic that fights bacteria in the body.
- Ciprofloxacin is an antibiotic used to treat a number of bacterial infections.
This is called her background risk. This sheet talks about whether exposure to ciprofloxacin may increase the risk for birth defects over that background risk. This information should not take the place of medical care and advice from your health care provider. Ciprofloxacin is an antibiotic used to treat a variety of bacterial infections.
It is part of a group of antibiotics called quinolones or fluoroquinolones. Is there an increased chance for miscarriage if I take ciprofloxacin during the first trimester?
Is there an increased chance for birth defects or pregnancy problems if I take ciprofloxacin during the first trimester? It is unlikely. Because these studies included women taking ciprofloxacin for only five to seven days, the effects of long-term use are not well known. However, there was not an increased chance for birth defects in a small number of babies exposed to longer periods of use. Is there an increased chance for harmful effects for the baby if I take ciprofloxacin in the second or third trimester?
There does not seem to be an increased chance for harmful effects on the baby if ciprofloxacin is taken later in pregnancy. While not likely to affect a pregnancy, ciprofloxacin has been associated with joint pain and, rarely, tendon rupture in the person taking the medication. Any joint pain due to ciprofloxacin typically goes away after stopping the medication. Ciprofloxacin is generally not used in pregnancy except for infections that cannot be treated with other antibiotics. It is unlikely that ciprofloxacin has a harmful effect on children and babies.
However, ciprofloxacin and its effect on joint development are still being studied and current studies are not enough to prove that there is no risk. If the infection does not respond to that treatment, then you and your health care provider may decide to use ciprofloxacin. There are a small number of studies on using ciprofloxacin while breastfeeding.
This amount would be much lower than the dose given directly to an infant when needed for a treatment. Like many other antibiotics, use of ciprofloxacin may cause problems in the infant such as diarrhea and yeast infection thrush or diaper rash. Be sure to talk to your healthcare provider about your breastfeeding questions. There are no studies looking at possible risks to a pregnancy when the father takes ciprofloxacin.
In general, exposures that fathers have are unlikely to increase risks to a pregnancy. Beth is a genetic counselor and pediatric nurse practitioner.
She was also a founding board member of OTIS. In the last few weeks, MotherToBaby, a service of the Organization of …. Help us help women and their healthcare providers as they make treatment choices in pregnancy and while breastfeeding. You have questions. We have answers.
Email An Expert. Fact Sheets. What is ciprofloxacin? Can I take ciprofloxacin if I am breastfeeding? What if the father of the baby takes ciprofloxacin? The transfer of drugs and other chemicals into human milk. Pediatrics Management of asymptomatic pregnant or lactating women exposed to anthrax. Int J Gynecol Obstet Berkovitch M, et al.
Safety of the new quinolones in pregnancy. Obstet Gynecol 84 4 Bomford JAL, et al. Ciprofloxacin use during pregnancy. Drugs 45 S3 : Gardner D, et al. Simultaneous concentrations of ciprofloxacin in breast milk and in serum in mother and breast-fed infant. Clin Pharm Kabeya CM, et al. Ciprofloxacin for multiresistant enteric fever in pregnancy. The Lancet Use of ciprofloxacin during breastfeeding. Can Fam Physician 61 4 Leung D, et al. Treatment of typhoid in pregnancy. Loebstein R, et al.
Pregnancy outcome following gestational exposure to fluoroquinolones: a multicenter prospective controlled study. Antimicrob Agents Chemother 42 6 Meaney-Delman D, et al. Obstet Gynecol. Antibiotic use in pregnancy and lactation. Obstet Gynecol 5 Padberg S, Wacker E, et al.
Observational cohort study of pregnancy outcomes after first-trimester exposure to fluoroquinolones. Agents Chemother. Polacheck H, et al. Transfer of ciprofloxacin, ofloxacin and levofloxacin across the perfused human placenta in vitro. Eur J Obstet Gynecol Schaefer C, et al. Schluter G. Ciprofloxacin: toxicologic evaluation of additional safety data.
Stahlmann R, et al. Chondrotoxicity and toxicokinetics of sparfloxacin in juvenile rats. Yefet E, et al. Health Professionals Fact Sheets F. View PDF Version. The ability to consult with Ms. Lori Wolfe to review the literature helps guide me in my treatment of women who wish to become pregnant or are pregnant.
Ms Wolfe is always professional and skilled in her mastery of the current literature as it relates to the safety of using psychotropic medications in the pregnant or breastfeeding patient. I find their services crucial to assist me in continuing to give the best care I can to my patients. Geralyn Carducci, Psychiatrist, WI. Meet An Expert. Connect With Us. E-News Sign Up.
It is available as a generic medication and not very expensive. Ciprofloxacin is found in breast milk , and depending on how long ago the mother took the medication, the baby can take in the medication while breastfeeding. Nitro- imidazole derivatives Metronidazole Tinidazole Ornidazole. One of our editors will review your suggestion and make changes if warranted. Last updated on Jan 7, In the US Michigan Medicaid surveillance study of , pregnancies, major birth defects were reported in 3 of exposed neonates.
Ciprofloxacin and pregnancy. Ciprofloxacin
Retrieved 23 August Retrieved 22 February The Journal of Family Practice. Australian Government. Archived from the original on 8 April The Journal of Antimicrobial Chemotherapy. American Family Physician. OUP Oxford. Archived from the original on 8 September Robin Analogue-based Drug Discovery. World Health Organization. April Archived PDF from the original on 13 December Retrieved 8 December Tarascon pharmacopoeia 15 ed. International Drug Price Indicator Guide.
Retrieved 24 August Retrieved 22 December Clinical Infectious Diseases. European Association of Urology. Archived from the original PDF on 31 December June Archived PDF from the original on 24 April Retrieved 31 August Archived PDF from the original on 22 July Morbidity and Mortality Weekly Report. Archived from the original on 8 December July An example from neurology and neurorehabilitation]". Wiener Medizinische Wochenschrift. Antimicrobial Agents and Chemotherapy. Comparative Biochemistry and Physiology.
Food and Drug Administration. Archived PDF from the original on 18 October Retrieved 7 September Korean Journal of Pediatrics. Pharmcards review cards for medical students 4th ed.
Retrieved 26 February Greek Network for the Surveillance of Antimicrobial Resistance". Emerging Infectious Diseases. Minnesota Department of Health.
Archived from the original on 5 March International Symposium on Antimicrobial Agents and Resistance Archived from the original on 9 March Retrieved 12 August Archived from the original PDF on 9 October Retrieved 20 June The American Journal of Medicine. Archived PDF from the original on 17 October Retrieved 1 April Retrieved 10 January Mayo Clinic Proceedings.
Family Practice. November Drug Saf. Drug Safety. Archived from the original on 28 May Retrieved 13 October A review of the evidence". Current Medical Research and Opinion. Retrieved 4 January American Journal of Health-System Pharmacy. US Food and Drug Administration. Archived PDF from the original on 5 July Retrieved 8 September Archived PDF from the original on 14 December Current Medicinal Chemistry. Pakistan Journal of Pharmaceutical Sciences.
Supportive Care in Cancer. McGraw-Hill Medical. Microbiology and Molecular Biology Reviews. Archived PDF from the original on 30 December Archived from the original PDF on 30 December Archived from the original PDF on 15 December Retrieved 2 November The Medical Clinics of North America.
Archived from the original on 6 January Retrieved 5 January Archived from the original on 9 July Archived from the original PDF on 27 August Retrieved 4 September USA: Postal Reporter.
Archived from the original on 21 October Retrieved 9 September European Journal of Medicinal Chemistry. Medical portal Pharmacy and pharmacology portal. Antibacterials : nucleic acid inhibitors J01E , J01M. Sulfamethoxazole Sulfadiazine Sulfamoxole. Sulfacetamide Sulfadicramide Sulfametrole Sulfanitran.
Aminocoumarins : Novobiocin. Metronidazole Tinidazole Ornidazole. Atevirdine Azaperone Delavirdine Mirtazapine Pyridinylpiperazine. There is no conclusive evidence that using ciprofloxacin in pregnancy is unsafe, but according to some studies on animals, the medication can negatively affect a fetus. In addition, while no studies have been specifically done on ciprofloxacin and its effects on human pregnancies, the medication is known to make its way into amniotic fluid, the fluid that surrounds a fetus in the womb.
As the effects of the medication are largely unknown at that point in pregnancy, women are advised to avoid ciprofloxacin in pregnancy in general — unless a doctor deems the benefits of the medication as outweighing the risks. Since the safety of taking ciprofloxacin in pregnancy is not yet known, it is understood that women who are breastfeeding or plan to breastfeed should not use the medication as well. The evidence suggests that breastfeeding while using ciprofloxacin can cause serious medical conditions for the breastfeeding baby.
Ciprofloxacin is found in breast milk , and depending on how long ago the mother took the medication, the baby can take in the medication while breastfeeding. Ciprofloxacin itself is an antibiotic , meaning it is a medication used to fight bacterial infections.
Ciprofloxacin comes in a tablet and extended release tablet form, as well as in a liquid form. It is important to follow the dosage as prescribed by a doctor and not replace one type of ciprofloxacin with another. For example, a person who is taking the tablet form of ciprofloxacin should not substitute his prescription with the extended release tablet form. As with all medications, ciprofloxacin might cause side effects to occur. Common side effects include abdominal pain, diarrhea and headache, as well as nausea and vomiting.
Other serious side effects are seizure, severe skin reaction and unusual behavior or thoughts. I would think twice before using ciprofloxacin while breastfeeding.
But it's okay while pregnant if there is a serious infection and if the doctor recommends it. Your doctor will not prescribe something while you are pregnant unless he or she feels that it's necessary. UTIs can be dangerous for you and the baby. You could even go into premature labor from the infection. So the risks from the infection are greater, take your medication and don't worry.
SarahGen Post 1 I have urinary tract infection and I'm in my second trimester. My doctor prescribed me ciprofloxacin today. I'm going to start the medication but I'm worried about the potential side effects for the fetus. Just wondering, has anyone here taken this antibiotic while pregnant? Did you or your baby experience any problems? Please let me know!
Ciprofloxacin Use by Pregnant and Lactating Women | FDA
Ciprofloxacin is a prescription medication used to treat a variety of bacterial infections including urinary tract infections, pneumonia, and sinus infections.
Ciprofloxacin belongs to a group of antibiotics called fluoroquinolones, which work by killing the bacteria that cause infections. This medication comes as a tablet, an oral suspension liquid , and an intravenous IV solution. The tablet and suspension are usually taken twice daily, in the morning and evening, with or without food.
Ciprofloxacin also comes as an extended-release tablet that is taken once a day, with or without food. Swallow ciprofloxacin tablets whole. Do not split, crush, or chew tablets. Common side effects include nausea, vomiting, and diarrhea. Ciprofloxacin can cause dizziness. Do not drive or operate machinery until you know how ciprofloxacin affects you. It is used to treat a variety of infections, some of which include infections of the:.
This medication may be prescribed for other uses. This is not a complete list of ciprofloxacin side effects. Tell your doctor about any side effect that bothers you, or that does not go away. Call your doctor for medical advice about side effects.
Ciprofloxacin and other medicines can affect each other causing side effects. Especially tell your doctor if you take:. Certain medicines may keep ciprofloxacin from working correctly.
Take ciprofloxacin either 2 hours before or 6 hours after taking these products:. Know the medicines you take. Keep a list of your medicines and show it to your doctor and pharmacist when you get a new medicine.
Ciprofloxacin belongs to a class of antibiotics called fluoroquinolones. Ciprofloxacin can cause side effects that may be serious or even cause death. If you get any of the following serious side effects, get medical help right away. Talk with your healthcare provider about whether you should continue to take ciprofloxacin.
Fluoroquinolones like ciprofloxacin may cause worsening of myasthenia gravis symptoms, including muscle weakness and breathing problems. Call your healthcare provider right away if you have any worsening muscle weakness or breathing problems. Medications can interact with certain foods. In some cases, this may be harmful and your doctor may advise you to avoid certain foods.
Caffeine-containing products include coffee, tea, energy drinks, soft drinks colas , chocolate, and other foods and beverages. The FDA categorizes medications based on safety for use during pregnancy. Five categories - A, B, C, D, and X, are used to classify the possible risks to an unborn baby when a medication is taken during pregnancy. There are no well-controlled studies that have been done in pregnant women. Ciprofloxacin should be used during pregnancy only if the possible benefit outweighs the possible risk to the unborn baby.
Ciprofloxacin has been detected in human breast milk. Because of the possibility for adverse reactions in nursing infants from ciprofloxacin, a choice should be made whether to stop nursing or to stop use of this medication.
The importance of the drug to the mother should be considered. If you miss a dose, take the missed dose as soon as you remember. Do not take two doses of ciprofloxacin at the same time. Finish your prescribed treatment, unless:. Take ciprofloxacin exactly as prescribed by your doctor. Follow the directions on your prescription label carefully.
Doses vary, but usually range between mg to mg every 12 hours. Ciprofloxacin is often prescribed for 7 to 14 days, although sometimes it can be prescribed as a single dose or for treatment lasting 60 days. If you take too much ciprofloxacin, call your healthcare provider or get medical help immediately. Fluoroquinolones, including ciprofloxacin, are associated with an increased risk of tendinitis and tendon rupture in all ages. This risk is further increased in older patients usually over 60 years of age, in patients taking corticosteroid drugs, and in patients with kidney, heart or lung transplants.
Fluoroquinolones, including ciprofloxacin, may exacerbate muscle weakness in persons with myasthenia gravis. Avoid ciprofloxacin in patients with known history of myasthenia gravis. Ciprofloxacin is an antibiotic and treats infection. Ciprofloxacin can cause tendon rupture. Pharmacist Jobby John, PharmD summarizes the uses, common side effects, and warnings for the Fluoroquinolones class of medications.
Patient Ratings for Ciprofloxacin. How was your experience with Ciprofloxacin? First, a little about yourself Male Female. What tips would you provide a friend before taking Ciprofloxacin? Choose one. Back Next. How well did Ciprofloxacin work for you? Did you experience many side effects while taking this drug?
How likely would you be to recommend Ciprofloxacin to a friend? Back Submit. Ciprofloxacin Cautionary Labels Back to Top. Uses of Ciprofloxacin Back to Top. Ciprofloxacin Brand Names Back to Top. Ciprofloxacin Drug Class Back to Top. Ciprofloxacin is part of the drug class: Fluoroquinolones. Side Effects of Ciprofloxacin Back to Top.
Serious side effects have been reported with ciprofloxacin. See "Drug Precautions" section. Common side effects include: nausea diarrhea changes in liver function tests vomiting rash vaginal yeast infection pain or discomfort in the abdomen headache This is not a complete list of ciprofloxacin side effects. Ciprofloxacin Interactions Back to Top.
Taking an NSAID while you take ciprofloxacin or other fluoroquinolones may increase your risk of central nervous system effects and seizures. You should not take ciprofloxacin if you are already taking tizanidine. Corticosteroids taken by mouth or by injection may increase the chance of tendon injury. Take ciprofloxacin either 2 hours before or 6 hours after taking these products: an antacid, multivitamin, or other product that has magnesium, calcium, aluminum, iron, or zinc sucralfate Carafate.
Ask your doctor or pharmacist if you are not sure if any of your medicines are listed above. Ciprofloxacin Precautions Back to Top. Tendon rupture or swelling of the tendon tendinitis Tendon problems can happen in people of all ages who take ciprofloxacin. Tendons are tough cords of tissue that connect muscles to bones. Symptoms of tendon problems may include: Pain, swelling, tears and inflammation of tendons including the back of the ankle Achilles , shoulder, hand, or other tendon sites.
The risk of getting tendon problems while you take ciprofloxacin is higher if you: are over 60 years of age are taking steroids corticosteroids have had a kidney, heart or lung transplant Tendon problems can happen in people who do not have the above risk factors when they take ciprofloxacin.
Other reasons that can increase your risk of tendon problems can include: physical activity or exercise kidney failure tendon problems in the past, such as in people with rheumatoid arthritis RA Call your healthcare provider right away at the first sign of tendon pain, swelling or inflammation. Stop taking ciprofloxacin until tendinitis or tendon rupture has been ruled out by your healthcare provider.
Avoid exercise and using the affected area. This can also happen with other tendons. Talk to your healthcare provider about the risk of tendon rupture with continued use of ciprofloxacin. You may need a different antibiotic that is not a fluoroquinolone to treat your infection. Tendon rupture can happen while you are taking or after you have finished taking ciprofloxacin.
Tendon ruptures have happened up to several months after patients have finished taking their fluoroquinolone. Get medical help right away if you get any of the following signs or symptoms of a tendon rupture: hear or feel a snap or pop in a tendon area bruising right after an injury in a tendon area unable to move the affected area or bear weight 2. Other serious side effects of ciprofloxacin include: You may have serious seizure and breathing problems when you take theophylline with ciprofloxacin.
These problems may lead to death. Get emergency help right away if you have seizures or trouble breathing. Seizures have been reported in people who take fluoroquinolone antibiotics including ciprofloxacin.
Tell your healthcare provider if you have a history of seizures. Ask your healthcare provider whether taking ciprofloxacin will change your risk of having a seizure. Stop taking ciprofloxacin and get emergency medical help right away if you get any of the following symptoms of a severe allergic reaction: hives trouble breathing or swallowing swelling of the lips, tongue, face throat tightness, hoarseness rapid heartbeat faint yellowing of the skin or eyes.
Stop taking ciprofloxacin and tell your healthcare provider right away if you get yellowing of your skin or white part of your eyes, or if you have dark urine.